Our Stolen Futurea book by Theo Colborn, Dianne Dumanoski, and John Peterson Myers
 
 

 

 
Emerging studies examining links between
endocrine disrupting contaminants and cancer
 
   

Newbold, RR, EP Banks, B Bullock, and WN Jefferson 2001. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Research 61: 4325-4328.


Newbold et al. report that when neonatal mice are exposed to genistein—a phytoestrogen present in soy—later in life they develop uterine cancer of the same form caused by diethylstilbestrol (DES). The levels of genistein used in these experiments are comparable to those found in infant formula based on soy. More...


Weir, HK, LD Marrett, N Kreiger, GA Darlington and L Sugar. 2000. Pre-natal and peri-natal exposures and risk of testicular germ cell cancers. International Journal of Cancer 87:438-443.


This case control study found a positive association between exogenous estrogens (DES and premarin) and risk of testicular cancer. "Not only does exposure to elevated levels (exogenous hormone use, pre-term birth, and first birth among young mothers) increase risk, but also exposure to relatively lower levels (heavy cigarette consumption, and perhaps, bleeding and threatened miscarriage) may decrease cancer risk." More...


 

  Porta, M, N Malats, M Jariod, JO Grimalt, J Rifa, A Carrato, L Guarner, A Salas, M Santiago-Silva, JM Corominas, M Andreu, FX Real. 1999. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. The Lancet 354:2125-2129

The etiology of pancreatic cancer is poorly understood. Only one risk factor, smoking, has been established firmly. Epidemiological studies have hinted at a link to DDT exposure, but in general have found little or no association. The results presented by Porta et al. "suggest that organochlorine compounds such as p,p'-DDT, p,p'-DDE and some PCBs could play a part in the pathogenesis of exocrine pancreatic cancer through modulation of K-ras activation." The results, however, do not allow causal conclusions to be drawn. More...


 
   
   
   
   
   

 

 

 

OSF Home
 About this website
Newest
Book Basics
  Synopsis & excerpts
  The bottom line
  Key points
  The big challenge
  Chemicals implicated
  The controversy
  Recommendations
New Science
  Broad trends
  Basic mechanisms
  Brain & behavior
  Disease resistance
  Human impacts
  Low dose effects
  Mixtures and synergy
  Ubiquity of exposure
  Natural vs. synthetic
  New exposures
  Reproduction
  Wildlife impacts
Recent Important    Results
Consensus
News/Opinion
Myths vs. Reality
Useful Links
Important Events
Important Books
Other Sources
Other Languages
About the Authors
 

Talk to us: email