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------=_NextPart_01C3DF71.725AAEF0 Content-Location: file:///C:/902B91EB/CHE_talk_files/master04.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C3DF71.725AAEF0 Content-Location: file:///C:/902B91EB/CHE_talk_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C3DF71.725AAEF0 Content-Location: file:///C:/902B91EB/CHE_talk_files/editdata.mso Content-Transfer-Encoding: base64 Content-Type: application/x-mso QWN0aXZlTWltZQAAAfAEAAAA/////wAAA/BEAAAADwCIFzwAAAAAAIkXNAAAAAAAAAAAAAAAAAAA AFgCAAAAAQEAAQEAAAEBAQABAAAAAAAAAKBaAAAAAAAAAAAAAIACAeAAAAvwBAAAABI0Vng= ------=_NextPart_01C3DF71.725AAEF0 Content-Location: file:///C:/902B91EB/CHE_talk_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="windows-1252" PowerPoint Presentation
Embryonic Origin of Adult Disease: Altered Gene Expression
CHE Phone Conference
21 Jan 2004
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Disease - The Dogma
Genes
Germs
Environment
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Disease= - Medical School Training
Genes
Germs
Environment
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Disease - Future?
Genes
Germs
Environment
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Environ= ment - What Environment ?
•<= /span>Internal
–= Egg and sperm development
–= Uterus/egg
•<= /span>External
–= Nest/home
–= Community/Ecosystem
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HO
H3C
OH
=
= ER
=
= ER
HO
H3C
OH
HO
H3C
OH
TATA
ERE <= /div>
HO
H3C
OH
=
= ER
H3C
HO
OH
=
= ER
RNA
Pol
OH
HO
H3C
Target Genes:&= #13;
<= span style=3D'font-family:Helvetica;font-size:67%;color:white;mso-color-index:0= '>•<= /span>Progesterone Receptor
<= span style=3D'font-family:Helvetica;font-size:67%;color:white;mso-color-index:0= '>•= Lactoferrin
Couse, 2003
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